what is Abiraterone by AI

 Abiraterone (brand name: Zytiga) is a hormonal therapy (androgen biosynthesis inhibitor) used primarily to treat prostate cancer, specifically:

Approved Uses

  • Metastatic castration-resistant prostate cancer (mCRPC)

  • Metastatic high-risk castration-sensitive prostate cancer (mCSPC)
    It is typically used in combination with prednisone.

How It Works

  • Abiraterone inhibits CYP17, an enzyme critical for androgen (testosterone) production.

  • By blocking this enzyme, abiraterone reduces androgen levels not only in the testes but also in the adrenal glands and tumor itself.

  • Since prostate cancer cells often rely on androgens to grow, lowering androgen levels slows the progression of the disease.

Administration

  • Taken orally as a tablet.

  • Must be taken on an empty stomach (food increases absorption significantly, which can increase side effects).

  • Prednisone is given to counteract side effects from suppressed cortisol production.

Common Side Effects

  • High blood pressure

  • Low potassium (hypokalemia)

  • Fluid retention

  • Joint or muscle pain

  • Liver function abnormalities

Warnings

  • Can cause adrenal insufficiency, liver toxicity, and cardiovascular issues.

  • Not recommended in women, especially pregnant women, due to potential for fetal harm.

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